Factors Influencing Allopurinol Initiation in Primary Care

被引：6

作者：

Clarson, Lorna E. ^{[1
]}

Hider, Samantha L. ^{[1
,2
]}

Belcher, John ^{[1
]}

Roddy, Edward ^{[1
,2
]}

Mallen, Christian D. ^{[1
]}

机构：

[1] Keele Univ, Res Inst Primary Care & Hlth Sci, Keele ST5 5BG, Staffs, England

[2] Staffordshire & Stoke On Trent Partnership NHS Tr, Haywood Hosp, Haywood Acad Rheumatol Ctr, Burslem, Staffs, England

来源：

ANNALS OF FAMILY MEDICINE | 2017年 / 15卷 / 06期

关键词：

gout; allopurinol; primary care; GENERAL-PRACTICE; GOUT; MANAGEMENT; RECOMMENDATIONS; BARRIERS; PATIENT;

D O I：

10.1370/afm.2137

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

100235 [预防医学];

摘要：

Despite guidance on appropriate initiation, urate-lowering therapy is prescribed for only a minority of patients with gout. Electronic health records for 8,142 patients with gout were used to investigate the effect of age, sex, comorbidities, number of consultations, and meeting internationally agreed eligibility criteria on time to allopurinol initiation. Time to first prescription was modeled using multilevel Cox proportional hazards regression. Allopurinol initiation was positively associated with meeting eligibility criteria at diagnosis of gout, but negatively associated with becoming eligible after diagnosis. Managing gout as a chronic disease, with regular reviews to discuss allopurinol treatment, may reduce barriers to treatment.

引用

页码：557 / 560

页数：4

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