Oxidation-Responsive Micelles Based on a Selenium-Containing Polymeric Superamphiphile

被引：122

作者：

Han, Peng ^{[1
]}

Ma, Ning ^{[1
]}

Ren, Huifeng ^{[1
]}

Xu, Huaping ^{[1
]}

Li, Zhibo ^{[2
]}

Wang, Zhiqiang ^{[1
]}

Zhang, Xi ^{[1
]}

机构：

[1] Tsinghua Univ, Dept Chem, Key Lab Organ Optoelect & Mol Engn, Beijing 100084, Peoples R China

[2] Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China

来源：

LANGMUIR | 2010年 / 26卷 / 18期

基金：

国家教育部博士点专项基金资助; 中国国家自然科学基金;

关键词：

CHARGED BLOCK-COPOLYMERS; GLUTATHIONE-PEROXIDASE; VESICLES; COMPLEXES; TRANSITION; SURFACTANT; BEHAVIOR; LENGTH; PAIR;

D O I：

10.1021/la102837a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have fabricated a polymeric superamphiphile based on the electrostatic interaction between the double hydrophilic block copolymer of poly(ethylene glycol)-b-acrylic acid (PEG-b-PAA) and a selenium-containing surfactant (SeQTA) The polymeric superamphiphiles are able to self-assemble to form micelles in solution The micelles can be disassembled with the addition of 0 1% H2O2 because SeQTA is very sensitive to oxidation The selenide group in SeQTA is oxidized into selenoxide (SeQTA-Ox) by H2O2, which makes the surfactant mole hydrophilic, thus leading to the disassembly of the micelles In addition, small guest molecules such as fluorescein sodium can be loaded into the micelles made from the polymeric superamphiphiles and released in a controlled way under mild oxidation conditions This study represents a new way to fabricate stimuli-responsive superamphiphiles for controlled self-assembly and disassembly

引用

页码：14414 / 14418

页数：5

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