Effects of metals Cu, Fe, Ni, V, and Zn on rat lung epithelial cells

被引：77

作者：

Riley, MR ^{[1
]}

Boesewetter, DE ^{[1
]}

Kim, AM ^{[1
]}

Sirvent, FP ^{[1
]}

机构：

[1] Univ Arizona, Dept Agr & Biosyst Engn, Tucson, AZ 85721 USA

来源：

TOXICOLOGY | 2003年 / 190卷 / 03期

关键词：

particulate matter; epithelial cell; cell death;

D O I：

10.1016/S0300-483X(03)00162-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Inhalation of combustion-derived particulate matter can have a variety of negative impacts on human health. Metals are known to play a substantial role in these effects, however, the interactions between cellular responses caused by multiple metals is not well understood. The impact of metals (Zn, Cu, Ni, V, and Fe) individually and in combination on a rat lung epithelial cell line (RLE-6TN) was evaluated. Quantifications involved measurement of inhibition of cell culture metabolism (mitochondrial succinate dehydrogenasc activity), cell death, mechanisms of cell death, and cytokine secretion. The ranking of metal toxicity based on TC50 values is V > Zn > Cu > Ni > Fe. Interactions were observed for exposures containing multiple metals: Zn + V, Zu + Cu, Zn + Fe, and Zn + Ni. Zn appears to diminish the negative impact of V and Cu; has ail additive effect with Ni, and has no substantial effect oil Fe toxicity. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：171 / 184

页数：14

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