Effectiveness of a single dose of acellular pertussis vaccine to prevent pertussis in children primed with pertussis whole cell vaccine

被引：7

作者：

De Serres, G

Shadmani, R

Boulianne, N

Duval, B

Rochette, L

Fradet, MD

Halperin, SA

机构：

[1] Inst Natl Sante Publ, Quebec City, PQ G1E 7G9, Canada

[2] CHU Laval, Res Ctr, Publ Hlth Res Unit, Quebec City, PQ G1V 4G2, Canada

[3] Minist Sante, Quebec City, PQ G1S 2M1, Canada

[4] Serv Sociaux Quebec, Quebec City, PQ G1S 2M1, Canada

[5] Dalhousie Univ, IWK Grace Ctr, Halifax, NS B3H 3J5, Canada

来源：

VACCINE | 2001年 / 19卷 / 20-22期

关键词：

pertussis; pertussis vaccine; vaccine efficacy; prevention and control; acellular pertussis vaccine;

D O I：

10.1016/S0264-410X(00)00545-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We estimated the protection given by one booster dose of acellular pertussis vaccine (aP) given at 18 months or before school entry to children already primed with whole cell vaccine (wP). Case-control studies were conducted in these two age groups. In children who received or were eligible to receive their 18 months booster, the risk of pertussis was 1.4 and 3.6 times higher for those with 4 and 3 wP, respectively, compared to those with 3 wP + 1 aP. In 5 and 6 yr old children, the risk of pertussis among the subjects with 5 and 4 wP, was 1.4 and 2.1 times higher respectively than in those who received 4 wP + 1 aP. A single dose of aP increased the protection against pertussis and this protection was greater than that obtained with a wP booster. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：3004 / 3008

页数：5

共 17 条

[1] Estimates of the effectiveness of a whole-cell pertussis vaccine from an outbreak in an immunized population [J].