pH sensitive alginate-chitosan hydrogel beads for carvedilol delivery

被引：23

作者：

Meng, Xun ^{[1
,2
]}

Li, Ping ^{[1
]}

Wei, Qin ^{[1
]}

Zhang, Hai-Xuan ^{[1
,2
]}

机构：

[1] Lanzhou Univ, Hosp 2, Lanzhou 730030, Peoples R China

[2] Lanzhou Univ, Coll Pharm, Lanzhou 73000, Peoples R China

来源：

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY | 2011年 / 16卷 / 01期

关键词：

pH-sensitive hydrogel; chitosan; carvedilol; swelling characteristics; delivery properties; DRUG-DELIVERY; POLYELECTROLYTE COMPLEX; ANTIHYPERTENSIVE AGENT; RELEASE; MICROSPHERES; VERAPAMIL; CALCIUM; SYSTEMS;

D O I：

10.3109/10837450903479947

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Alginate-chitosan hydrogel beads for carvedilol delivery were prepared to be used as a controlled pH-sensitive drug delivery system. The beads were characterized by scanning electron microscopy and Fourier transform infrared spectroscopy. The swelling ability and in vitro release of carvedilol in solutions of different pH value were investigated. They exhibited significant swelling rates when exposed to the slightly alkaline environment. The results suggest that the system has potential to be used as an effective pH-controlled delivery system for carvedilol. The release of carvedilol at various pH values was analyzed by a semi-empirical equation.

引用

页码：22 / 28

页数：7

共 28 条

[1]

Development of novel interpenetrating network gellan gum-poly(vinyl alcohol) hydrogel microspheres for the controlled release of carvedilol [J].