Immunological insights from genetic vaccines

被引：9

作者：

Ertl, HCJ ^{[1
]}

机构：

[1] Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA

来源：

VIRUS RESEARCH | 2005年 / 111卷 / 01期

关键词：

adenovirus vector; rabies virus; protective immunity; Simian origin vaccine vectors; mice;

D O I：

10.1016/j.virusres.2005.03.015

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学]; 100705 [微生物与生化药学];

摘要：

E1-deleted adenoviral vectors expressing the rabies virus glycoprotein rapidly induce protective titers of rabies virus neutralizing antibodies in adult and neonatal mice upon systemic or mucosal immunization. Pre-existing immunity in humans due to natural infections with common human serotypes of adenovirus such as the human serotype 5, most commonly used as a vaccine carrier can be circumvented by systemic immunization with a simian-origin adenovirus or by using the oral route of immunization. Virus neutralizing antibody titers can be enhanced by prime-boost regimens. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：89 / 92

页数：4

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