Pregnancy after intravenous pulsatile gonadotropin-releasing hormone in a hyperprolactinaemic woman resistant to treatment with dopamine agonists

It is difficult to achieve pregnancy in hyperprolactinaemic patients in whom prolactin inhibiting agents are ineffective. Medical treatment with bromocriptine, lisuride and the new agent CV 205-502 (quinagolide) was unsuccessful in normalizing hyperprolactinaemia in a 28 year-old woman to treat anovulatory infertility. Repeated Magnetic Resonance Imaging (MRI) was normal, with no images suggestive of prolactin adenoma. A live child was born after pulsatile GnRH treatment despite persistently elevated prolactin levels; normal MRI and decreased prolactin levels were observed after pregnancy. In summary, successful pregnancy can be obtained with pulsatile GnRH treatment in women resistant to old and new medical treatments of hyperprolactinaemia. (C) 1997 Elsevier Science Ireland Ltd.