Quantum molecular modeling of the elastinic tetrapeptide Val-Pro-Gly-Gly

被引：11

作者：

Broch, H

Moulabbi, M

Vasilescu, D

Tamburro, AM

机构：

[1] Univ Nice, Biophys Lab, GRECFO, F-06108 Nice 2, France

[2] Univ Basilicata, Dept Chem, I-85100 Potenza, Italy

来源：

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS | 1998年 / 15卷 / 06期

关键词：

D O I：

10.1080/07391102.1998.10509002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The free Val-Pro-Gly-Gly tetrapeptide belonging to the Proline-rich sequences of elastin has been studied both theoretically and experimentally.The molecular modelisation was carried out using AM1 and ab initio quantum computations while the conformation in solution was ascertained by circular dichroism spectroscopy performed on the synthesized tetrapeptide. Experimental and theoretical investigations lead to the conclusion that the most probable structure is constituted by a type II beta-turn.

引用

页码：1073 / 1091

页数：19

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