The Urabe AM9 mumps vaccine is a mixture of viruses differing at amino acid 335 of the hemagglutinin-neuraminidase gene with one form associated with disease

被引:39
作者
Brown, EG
Dimock, K
Wright, KE
机构
[1] Dept. of Microbiology and Immunology, Faculty of Medicine, University of Ottawa
[2] Dept. of Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ont. K1H 8M5
基金
加拿大自然科学与工程研究理事会;
关键词
D O I
10.1093/infdis/174.3.619
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The reason for the high incidence of vaccine-associated meningitis due to the Urabe AM9 vaccine was assessed by comparing the nucleotide (nt) sequence of the hemagglutinin-neuraminidase (HN) gene from vaccine virus to those of viruses isolated from persons with postvaccination meningitis. A G(1081)-->A nt substitution that was predicted to result in a Glu(335)-->Lys reversion in the HN protein was detected between Urabe AM9 (G) acid postvaccine meningitis mumps virus isolates (A). Further analysis showed that the Urabe AM9 vaccine was a mixture of viruses with wild type (A) and variant (G) nt at position 1081. Urabe AM9 vaccinees who developed meningitis or parotitis possessed predominantly A (98%-100%) at nt 1081, indicating strong selection of the wild type (A) form relative to the variant (G) form. Mumps virus homogeneous for the variant Glu(335) form of the HN gene may be safer than the original Urabe AM9 vaccine.
引用
收藏
页码:619 / 622
页数:4
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