Spatial control of exocytosis

被引：27

作者：

Spiliotis, ET ^{[1
]}

Nelson, WJ ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Mol & Cellular Physiol, Stanford, CA 94305 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2003年 / 15卷 / 04期

关键词：

D O I：

10.1016/S0955-0674(03)00074-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

During many key biological processes, exocytosis is confined to distinct regions of the plasma membrane. Spatial control of exocytosis correlates with altered membrane skeleton dynamics and assembly of local membrane microdomains. These domains act as local stages for the assembly and the regulation of molecular complexes (targeting patches) that mediate vesicle-membrane fusion. Furthermore, local activation of signaling pathways reinforces formation of these patches and might effect global repositioning of the secretory pathway toward sites of localized exocytosis.

引用

页码：430 / 437

页数：8

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