Modulation of neutrophil adhesion to vascular endothelial cells in rat experimental otitis media treated with a macrolide

被引：3

作者：

Enomoto, F

Kin, R

Kataoka, T

Yamazaki, Y

Yokoi, H

Fujimori, M

Nagaoka, I

Ichikawa, G

机构：

[1] Juntendo Univ, Sch Med, Dept Otorhinolaryngol, Bunkyo Ku, Tokyo 1138421, Japan

[2] Juntendo Univ, Urayasu Hosp, Dept Otorhinolaryngol, Bunkyo Ku, Tokyo 1138421, Japan

[3] Juntendo Univ, Sch Med, Dept Biochem, Bunkyo Ku, Tokyo 1138421, Japan

来源：

AURIS NASUS LARYNX | 2003年 / 30卷 / 03期

关键词：

endothelial cell; neutrophil; adhesion molecule; L-selectin; Mac-1;

D O I：

10.1016/S0385-8146(03)00097-X

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Object: We previously reported that erythromycin (EM) affected the adhesion molecules that interact with neutrophils and inhibited neutrophil infiltration in a rat experimental otitis media model. Purpose: The purpose of the present Study was to examine whether EM affects the adhesion of rat neutrophils to endothelial cells. Method: The adhesion of neutrophils to WK-5 endothelial cells was evaluated. One group of rats was given EM for 2 weeks, while the other group received no treatment. The adhesion of peripheral-blood neutrophils and neutrophils accumulated in the middle ear from these two groups were compared. Results: Two-week EM pretreatment inhibited adhesion of neutrophils to WK-5 cells. The adhesion of neutrophils accumulated in the middle ear cavity to WK-5 cells was significantly higher than that of peripheral-blood neutrophils from control rats. Conclusion: The results suggest that EM affects the adhesion of neutrophils to endothelial cells. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：247 / 251

页数：5

共 16 条

[1]

Enomoto F, 1998, ACTA OTO-LARYNGOL, P57

[2]

ENOMOTO F, 1998, NIPPON JIBIINNKOUKA, V98, P959

[3] Effects of macrolides on interleukin-8 secretion from human nasal epithelial cells [J].