Insulin action on the liver in vivo

被引：36

作者：

Cherrington, A. D. ^{[1
]}

Moore, M. C. ^{[1
]}

Sindelar, D. K. ^{[1
]}

Edgerton, D. S. ^{[1
]}

机构：

[1] Vanderbilt Univ, Sch Med, Dept Mol Physiol & Biophys, Nashville, TN 37232 USA

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2007年 / 35卷

关键词：

glucagon; hyperglycaemia; insulin; intralipid; liver; somatostatin;

D O I：

10.1042/BST0351171

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Insulin has a potent inhibitory effect on hepatic glucose production by direct action at hepatic receptors. The hormone also inhibits glucose production by suppressing both lipolysis in the fat cell and secretion of glucagon by the alpha-cell. Neural sensing of insulin levels appears to participate in control of hepatic glucose production in rodents, but a role for brain insulin sensing has not been documented in dogs or humans. The primary effect of insulin on the liver is its direct action.

引用

页码：1171 / 1174

页数：4

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