Polymorphism screening of four genes encoding advanced glycation end-product putative receptors - Association study with nephropathy in type 1 diabetic patients

被引:57
作者
Poirier, O
Nicaud, V
Vionnet, N
Raoux, S
Tarnow, L
Vlassara, H
Parving, HH
Cambien, F
机构
[1] INSERM U525 SC7, F-75005 Paris, France
[2] Steno Diabet Ctr, DK-2820 Gentofte, Denmark
[3] Mt Sinai Med Ctr, New York, NY 10029 USA
关键词
D O I
10.2337/diabetes.50.5.1214
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Advanced glycation end-products (AGEs) may play an important role in the pathogenesis and progression of cardiovascular and renal complications of diabetes. Four putative AGE receptors (RAGEs), AGE-R1, AGE-R2, and AGE-R3 have been described. in this study, me scanned the sequence of the genes encoding these AGE receptors in 48 patients with type 1 diabetes and investigated the identified polymorphisms (n = 19) in 199 type 1 diabetic patients with nephropathy and 193 type 1 diabetic patients without nephropathy. Overall, none of the polymorphisms was strongly associated with nephropathy The minor allele of a polymorphism located in the promoter region of the RAGE gene (C-1152A) conferred a weak protective effect (P < 0.05) and Was associated with a longer duration of nephropathy-free diabetes (P = 0.08).
引用
收藏
页码:1214 / 1218
页数:5
相关论文
共 25 条
[1]   THE NOVEL GENE G17, LOCATED IN THE HUMAN MAJOR HISTOCOMPATIBILITY COMPLEX, ENCODES PBX2, A HOMEODOMAIN-CONTAINING PROTEIN [J].
AGUADO, B ;
CAMPBELL, RD .
GENOMICS, 1995, 25 (03) :650-659
[2]  
ANDERSEN AR, 1983, DIABETOLOGIA, V25, P496
[3]   AMINOGUANIDINE PREVENTS DIABETES-INDUCED ARTERIAL-WALL PROTEIN CROSS-LINKING [J].
BROWNLEE, M ;
VLASSARA, H ;
KOONEY, A ;
ULRICH, P ;
CERAMI, A .
SCIENCE, 1986, 232 (4758) :1629-1632
[4]   LILLY LECTURE 1993 - GLYCATION AND DIABETIC COMPLICATIONS [J].
BROWNLEE, M .
DIABETES, 1994, 43 (06) :836-841
[5]   Sequence diversity in 36 candidate genes for cardiovascular disorders [J].
Cambien, F ;
Poirier, O ;
Nicaud, V ;
Herrmann, SM ;
Mallet, C ;
Ricard, S ;
Behague, I ;
Hallet, V ;
Blanc, H ;
Loukaci, V ;
Thillet, J ;
Evans, A ;
Ruidavets, JB ;
Arveiler, D ;
Luc, G ;
Tiret, L .
AMERICAN JOURNAL OF HUMAN GENETICS, 1999, 65 (01) :183-191
[6]   FAMILIAL CLUSTERING OF CARDIOVASCULAR-DISEASE IN PATIENTS WITH INSULIN-DEPENDENT DIABETES AND NEPHROPATHY [J].
EARLE, K ;
WALKER, J ;
HILL, C ;
VIBERTI, G .
NEW ENGLAND JOURNAL OF MEDICINE, 1992, 326 (10) :673-677
[7]   Is diabetic nephropathy inherited? Studies of glomerular structure in type 1 diabetic sibling pairs [J].
Fioretto, P ;
Steffes, MW ;
Barbosa, J ;
Rich, SS ;
Miller, ME ;
Mauer, M .
DIABETES, 1999, 48 (04) :865-869
[8]   Identification of p90, a prominent tyrosine-phosphorylated protein in fibroblast growth factor-stimulated cells, as 80K-H [J].
Goh, KC ;
Lim, YP ;
Ong, SH ;
Siak, CB ;
Cao, XM ;
Tan, YH ;
Guy, GR .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (10) :5832-5838
[9]   Differential expression of renal AGE-receptor genes in NOD mice: Possible role in nonobese diabetic renal disease [J].
He, CJ ;
Zheng, F ;
Stitt, S ;
Striker, L ;
Hattori, M ;
Vlassara, H .
KIDNEY INTERNATIONAL, 2000, 58 (05) :1931-1940
[10]   Identification of a three-amino acid deletion in the α2B-adrenergic receptor that is associated with reduced basal metabolic rate in obese subjects [J].
Heinonen, P ;
Koulu, M ;
Pesonen, U ;
Karvonen, MK ;
Rissanen, A ;
Laakso, M ;
Valve, R ;
Uusitupa, M ;
Scheinin, M .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1999, 84 (07) :2429-2433