Polymorphism screening of four genes encoding advanced glycation end-product putative receptors - Association study with nephropathy in type 1 diabetic patients
Advanced glycation end-products (AGEs) may play an important role in the pathogenesis and progression of cardiovascular and renal complications of diabetes. Four putative AGE receptors (RAGEs), AGE-R1, AGE-R2, and AGE-R3 have been described. in this study, me scanned the sequence of the genes encoding these AGE receptors in 48 patients with type 1 diabetes and investigated the identified polymorphisms (n = 19) in 199 type 1 diabetic patients with nephropathy and 193 type 1 diabetic patients without nephropathy. Overall, none of the polymorphisms was strongly associated with nephropathy The minor allele of a polymorphism located in the promoter region of the RAGE gene (C-1152A) conferred a weak protective effect (P < 0.05) and Was associated with a longer duration of nephropathy-free diabetes (P = 0.08).
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UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,METAB MED UNIT,4TH FLOOR HUNTS HOUSE,LONDON SE1 9RT,ENGLANDUNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,METAB MED UNIT,4TH FLOOR HUNTS HOUSE,LONDON SE1 9RT,ENGLAND
EARLE, K
;
WALKER, J
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UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,METAB MED UNIT,4TH FLOOR HUNTS HOUSE,LONDON SE1 9RT,ENGLANDUNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,METAB MED UNIT,4TH FLOOR HUNTS HOUSE,LONDON SE1 9RT,ENGLAND
WALKER, J
;
HILL, C
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UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,METAB MED UNIT,4TH FLOOR HUNTS HOUSE,LONDON SE1 9RT,ENGLANDUNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,METAB MED UNIT,4TH FLOOR HUNTS HOUSE,LONDON SE1 9RT,ENGLAND
HILL, C
;
VIBERTI, G
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UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,METAB MED UNIT,4TH FLOOR HUNTS HOUSE,LONDON SE1 9RT,ENGLANDUNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,METAB MED UNIT,4TH FLOOR HUNTS HOUSE,LONDON SE1 9RT,ENGLAND
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UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,METAB MED UNIT,4TH FLOOR HUNTS HOUSE,LONDON SE1 9RT,ENGLANDUNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,METAB MED UNIT,4TH FLOOR HUNTS HOUSE,LONDON SE1 9RT,ENGLAND
EARLE, K
;
WALKER, J
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UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,METAB MED UNIT,4TH FLOOR HUNTS HOUSE,LONDON SE1 9RT,ENGLANDUNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,METAB MED UNIT,4TH FLOOR HUNTS HOUSE,LONDON SE1 9RT,ENGLAND
WALKER, J
;
HILL, C
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机构:
UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,METAB MED UNIT,4TH FLOOR HUNTS HOUSE,LONDON SE1 9RT,ENGLANDUNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,METAB MED UNIT,4TH FLOOR HUNTS HOUSE,LONDON SE1 9RT,ENGLAND
HILL, C
;
VIBERTI, G
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h-index: 0
机构:
UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,METAB MED UNIT,4TH FLOOR HUNTS HOUSE,LONDON SE1 9RT,ENGLANDUNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,METAB MED UNIT,4TH FLOOR HUNTS HOUSE,LONDON SE1 9RT,ENGLAND