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An asymmetric approach to coumarin anticoagulants via hetero-Diels-Alder cycloaddition

被引：170
作者：
Cravotto, G
Nano, GM
Palmisano, G
Tagliapietra, S
机构：
[1] Dipartimento Sci Chim Fis & Matemat, I-22100 Como, Italy
[2] Dipartimento Sci & Tecnol Farmaco, I-10125 Turin, Italy
来源：
TETRAHEDRON-ASYMMETRY | 2001年 / 12卷 / 05期
关键词：
D O I：
10.1016/S0957-4166(01)00124-0
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
We have developed a general, two-step protocol for the synthesis of chiral non-racemic coumarin anticoagulants (e.g. warfarin. coumachlor and acenocoumarol). This approach features a one-pot three-component tandem Knoevenagel-hetero-Diels-Alder reaction between in situ generated 3-arylidene-2,4-chromanediones and iso-propenyl ether derived from (-)-menthol. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
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页码：707 / 709
页数：3
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