β subunits of voltage-gated calcium channels

被引：285

作者：

Dolphin, AC ^{[1
]}

机构：

[1] UCL, Dept Pharmacol, London WC1E 6BT, England

来源：

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES | 2003年 / 35卷 / 06期

关键词：

calcium channel; beta subunit; palmitoylation; phosphorylation; trafficking; gene targeting; G-protein; assembly; inactivation; I-II LINKER; G-PROTEIN INHIBITION; GUANYLATE KINASE DOMAINS; DEPENDENT CA2+ CHANNELS; SKELETAL-MUSCLE; MOLECULAR DETERMINANTS; ALPHA(1) SUBUNIT; CHARGE MOVEMENT; INTRAMOLECULAR INTERACTION; FUNCTIONAL EXPRESSION;

D O I：

10.1023/B:JOBB.0000008026.37790.5a

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Calcium channel beta subunits have marked effects on the trafficking and on several of the biophysical properties of all high voltage activated calcium channels. In this article I shall review information on the different genes, on the structure of the beta subunits, and on their differential expression and post-translational modification. Their role in trafficking and assembly of the calcium channel heteromultimer will be described, and I will then review their effects on voltage-dependent and kinetic properties, stressing the differences between palmitoylated beta2a and the other beta subunits. Evidence for effects on calcium channel pharmacology will also be examined. I shall discuss the hypothesis that beta subunits can bind reversibly to calcium channels, and examine their role in the G protein modulation of calcium channels. Finally, I shall describe the consequences of knock-out of different beta subunit genes, and describe evidence for the involvement of beta subunits in disease.

引用

页码：599 / 620

页数：22

共 170 条

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