The Roles of MicroRNAs in Heart Diseases: A Novel Important Regulator

被引:66
作者
Cai, B. Z. [1 ]
Pan, Z. W. [1 ]
Lu, Y. J. [1 ,2 ]
机构
[1] Harbin Med Univ, Dept Pharmacol, Harbin 150081, Heilongjiang Pr, Peoples R China
[2] Harbin Med Univ, State Prov Key Lab Biomed & Pharmaceut, Harbin 150081, Heilongjiang Pr, Peoples R China
基金
中国国家自然科学基金;
关键词
microRNAs; development; arrhythmias; hypertrophy; ischemia; MUSCLE-SPECIFIC MICRORNA; CHANNEL GENES HCN2; DOWN-REGULATION; CARDIAC-HYPERTROPHY; SMALL RNAS; EXPRESSION; APOPTOSIS; MIR-133; K+; DIFFERENTIATION;
D O I
10.2174/092986710790226129
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
MicroRNAs (miRNAs) are non-coding single-stranded RNAs with about 21 similar to 23 nucleotides in length, which originate from encoding genes in nucleus. In most cases miRNAs play an inhibitory role in gene expression in a post-transcriptional level by partially complementary binding to the 3' unstranlated region (UTR) of target mRNAs. Large bodies of evidence have shown that miRNAs were involved in various diseases, such as cancer, infectious diseases, diabetes etc, and rising as critical modulators of pathological processes. Lately, some highlight articles revealed that the altered expression of miRNAs such as miR-1, miR-133, miR-21, miR-208 etc in hearts also contributed to cardiovascular diseases, such as heart ischemia, cardiac hypertrophy, and arrhythmias. Moreover, miRNAs are also identified to regulate heart development. These exciting findings not only improve our understanding of the molecular mechanisms of heart diseases, but also provide a new class of potential molecular targets miRNAs, for the development of novel agents to treat heart diseases. Here, we summarized the recent discoveries about the role of miRNAs in cardiac physiological and pathological functions, and then discussed about their therapeutic potentials for heart diseases.
引用
收藏
页码:407 / 411
页数:5
相关论文
共 49 条
[1]   CaM kinase II selectively signals to histone deacetylase 4 during cardiornyocyte hypertrophy [J].
Backs, Johannes ;
Song, Kunhua ;
Bezprozvannaya, Svetlana ;
Chang, Shurong ;
Olson, Eric N. .
JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (07) :1853-1864
[2]   Homocysteine modulates sodium channel currents in human atrial myocytes [J].
Cai, Benzhi ;
Shan, Luchen ;
Gong, Dongmei ;
Pan, Zhenwei ;
Ai, Jing ;
Xu, Changqing ;
Lu, Yanjie ;
Yang, Baofeng .
TOXICOLOGY, 2009, 256 (03) :201-206
[3]   MicroRNA-133 controls cardiac hypertrophy [J].
Care, Alessandra ;
Catalucci, Daniele ;
Felicetti, Federica ;
Bonci, Desiree ;
Addario, Antonio ;
Gallo, Paolo ;
Bang, Marie-Louise ;
Segnalini, Patrizia ;
Gu, Yusu ;
Dalton, Nancy D. ;
Elia, Leonardo ;
Latronico, Michael V. G. ;
Hoydal, Morten ;
Autore, Camillo ;
Russo, Matteo A. ;
Dorn, Gerald W., II ;
Ellingsen, Oyvind ;
Ruiz-Lozano, Pilar ;
Peterson, Kirk L. ;
Croce, Carlo M. ;
Peschle, Cesare ;
Condorelli, Gianluigi .
NATURE MEDICINE, 2007, 13 (05) :613-618
[4]   The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation [J].
Chen, JF ;
Mandel, EM ;
Thomson, JM ;
Wu, QL ;
Callis, TE ;
Hammond, SM ;
Conlon, FL ;
Wang, DZ .
NATURE GENETICS, 2006, 38 (02) :228-233
[5]   REGULATION OF CARDIAC GENE-EXPRESSION DURING MYOCARDIAL GROWTH AND HYPERTROPHY - MOLECULAR STUDIES OF AN ADAPTIVE PHYSIOLOGICAL-RESPONSE [J].
CHIEN, KR ;
KNOWLTON, KU ;
ZHU, H ;
CHIEN, S .
FASEB JOURNAL, 1991, 5 (15) :3037-3046
[6]   MicroRNA Expression Signature and the Role of MicroRNA-21 in the Early Phase of Acute Myocardial Infarction [J].
Dong, Shimin ;
Cheng, Yunhui ;
Yang, Jian ;
Li, Jingyuan ;
Liu, Xiaojun ;
Wang, Xiaobin ;
Wang, Dong ;
Krall, Thomas J. ;
Delphin, Ellise S. ;
Zhang, Chunxiang .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (43) :29514-29525
[7]  
DU ZM, 2000, CHIN PHARM J, V10, P18
[8]   MicroRNAs regulate brain morphogenesis in zebrafish [J].
Giraldez, AJ ;
Cinalli, RM ;
Glasner, ME ;
Enright, AJ ;
Thomson, JM ;
Baskerville, S ;
Hammond, SM ;
Bartel, DP ;
Schier, AF .
SCIENCE, 2005, 308 (5723) :833-838
[9]   Characterization and comparison of Na+, K+ and Ca2+ currents between myocytes from human atrial right appendage and atrial septum [J].
Gong, Dongmei ;
Zhang, Yong ;
Cai, Benzhi ;
Meng, Qingxin ;
Jiang, Shulin ;
Li, Xia ;
Shan, Luchen ;
Liu, Yanyan ;
Qiao, Guofen ;
Lu, Yanjie ;
Yang, Baofeng .
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2008, 21 (5-6) :385-394
[10]   The Microprocessor complex mediates the genesis of microRNAs [J].
Gregory, RI ;
Yan, KP ;
Amuthan, G ;
Chendrimada, T ;
Doratotaj, B ;
Cooch, N ;
Shiekhattar, R .
NATURE, 2004, 432 (7014) :235-240