Biology of glioma cancer stem cells

被引：140

作者：

Park, Deric M. ^{[1
,2
,3
]}

Rich, Jeremy N. ^{[4
]}

机构：

[1] Univ Pittsburgh, Inst Canc, Pittsburgh, PA 15260 USA

[2] Univ Pittsburgh, Dept Neurol Surg, Pittsburgh, PA 15260 USA

[3] Univ Pittsburgh, Dept Pharmacol & Chem Biol, Pittsburgh, PA USA

[4] Cleveland Clin, Dept Stem Cell Biol & Regenerat Med, Cleveland, OH 44106 USA

来源：

MOLECULES AND CELLS | 2009年 / 28卷 / 01期

关键词：

brain tumor; cancer stem cell; glioma; glioblastoma; BEVACIZUMAB PLUS IRINOTECAN; ACUTE MYELOID-LEUKEMIA; PROSPECTIVE IDENTIFICATION; NEURAL PROGENITORS; BRAIN CANCER; NF1; GENE; INACTIVATION; EXPRESSION; TEMOZOLOMIDE;

D O I：

10.1007/s10059-009-0111-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gliomas, much like other cancers, are composed of a heterogeneous mix of neoplastic and non-neoplastic cells that include both native and recruited cells. There is extensive diversity among the tumor cells, with differing capacity for in vitro and in vivo growth, a property intimately linked to the cell's differentiation status. Those cells that are undifferentiated, self-renewing, with the capacity for developing tumors (tumorigenic) cells are designated by some as cancer stem cells, because of the stem-like properties. These cells may be a critical therapeutic target. However the exact identity and cell(s) of origin of the so-called glioma cancer stem cell remain elusive. Here we review the current understanding of glioma cancer stem cell biology.

引用

页码：7 / 12

页数：6

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