A whole genome screen for association in Polish multiple sclerosis patients

被引：8

作者：

Bielecki, B

Mycko, MP

Tronczynska, E

Bieniek, M

Sawcer, S

Setakis, E

Benediktsson, K

Compston, A

Selmaj, KW

机构：

[1] Med Univ Lodz, Dept Neurol, PL-90153 Lodz, Poland

[2] Univ Cambridge, Addenbrookes Hosp, Neurol Unit, Cambridge CB2 2QQ, England

[3] Inst Publ Hlth, MRC Biostat Unit, Cambridge CB10 1SB, England

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2003年 / 143卷 / 1-2期

基金：

英国惠康基金;

关键词：

multiple sclerosis; linkage disequilibrium;

D O I：

10.1016/j.jneuroim.2003.08.022

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have performed the first systematic search for MS susceptibility genes completed in the Polish population. This screen was performed using 6000 microsatellite markers typed in pooled DNA from cases (n = 200), controls (n = 200) and trio families (n = 129). Five associated markers are identified, one (D6S2444) from the HLA region and four are from novel regions not previously associated with MS, 2p16 (D2S2153), 3p13 (D3S3568), 7p22 (D7S2521) and 15q26 (D15S649). (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：107 / 111

页数：5

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