Cartilage Acidic Protein-1B (LOTUS), an Endogenous Nogo Receptor Antagonist for Axon Tract Formation

被引：71

作者：

Sato, Yasufumi ^{[1
]}

Iketani, Masumi ^{[1
]}

Kurihara, Yuji ^{[1
]}

Yamaguchi, Megumi ^{[1
]}

Yamashita, Naoya ^{[1
]}

Nakamura, Fumio ^{[1
]}

Arie, Yuko ^{[1
]}

Kawasaki, Takahiko ^{[2
]}

Hirata, Tatsumi ^{[2
]}

Abe, Takaya ^{[3
]}

Kiyonari, Hiroshi ^{[3
]}

Strittmatter, Stephen M. ^{[4
,5
]}

Goshima, Yoshio ^{[1
,6
]}

Takei, Kohtaro ^{[1
,6
]}

机构：

[1] Yokohama City Univ, Grad Sch Med, Dept Mol Pharmacol & Neurobiol, Yokohama, Kanagawa 2360004, Japan

[2] Natl Inst Genet, Grad Sch Adv Studies, Div Brain Funct, Mishima, Shizuoka 4118540, Japan

[3] RIKEN Ctr Dev Biol, Lab Anim Resources & Genet Engn, Kobe, Hyogo 6500047, Japan

[4] Yale Univ, Sch Med, Dept Neurol, New Haven, CT 06520 USA

[5] Yale Univ, Sch Med, Neurobiol Sect, New Haven, CT 06510 USA

[6] Yokohama City Univ, Grad Sch Med, Adv Med Res Ctr, Yokohama, Kanagawa 2360004, Japan

来源：

SCIENCE | 2011年 / 333卷 / 6043期

基金：

日本科学技术振兴机构;

关键词：

LATERAL OLFACTORY TRACT; MITRAL CELL AXONS; NERVOUS-SYSTEM; IDENTIFICATION; REGENERATION; INHIBITION; EXPRESSION; GROWTH;

D O I：

10.1126/science.1204144

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Neural circuitry formation depends on the molecular control of axonal projection during development. By screening with fluorophore-assisted light inactivation in the developing mouse brain, we identified cartilage acidic protein-1B as a key molecule for lateral olfactory tract (LOT) formation and named it LOT usher substance (LOTUS). We further identified Nogo receptor-1 (NgR1) as a LOTUS-binding protein. NgR1 is a receptor of myelin-derived axon growth inhibitors, such as Nogo, which prevent neural regeneration in the adult. LOTUS suppressed Nogo-NgR1 binding and Nogo-induced growth cone collapse. A defasciculated LOT was present in lotus-deficient mice but not in mice lacking both lotus- and ngr1. These findings suggest that endogenous antagonism of NgR1 by LOTUS is crucial for normal LOT formation.

引用

页码：769 / 773

页数：5

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