KinMutBase, a database of human disease-causing protein kinase mutations

被引：18

作者：

Stenberg, KAE

Riikonen, PT

Vihinen, M

机构：

[1] Univ Helsinki, Dept Biosci, Div Biochem, FIN-00014 Helsinki, Finland

[2] Univ Tampere, Inst Med Technol, FIN-33101 Tampere, Finland

来源：

NUCLEIC ACIDS RESEARCH | 1999年 / 27卷 / 01期

关键词：

D O I：

10.1093/nar/27.1.362

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

KinMutBase (http://www.uta.fi/laitokset/imt/KinMutBase. html) is a registry of mutations in human protein kinases related to disorders. Kinases are essential cellular signalling molecules, in which mutations can lead into diseases including, e.g., immunodeficiencies, cancers and endocrine disorders. The first release of KinMutBase contains information for nine protein tyrosine kinases. There are altogether 170 entries representing 273 families and 403 patients. Mutations appear both in conserved hallmark residues of the kinases as well as in non-homologous sites. The KinMutBase WWW pages provide plenty of information, namely mutation statistics and display, clickable sequences with mutations, restriction enzyme patterns and online submission.

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页码：362 / 364

页数：3

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