An efficient synthesis of optically pure (S)-2-functionalized 1,2,3,4-tetrahydroquinoline

被引：9

作者：

Ding, K

Flippen-Anderson, J

Deschamps, JR

Wang, SM

机构：

[1] Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Med Chem, Ann Arbor, MI 48109 USA

[3] USN, Res Lab, Struct Matter Lab, Washington, DC 20375 USA

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 05期

关键词：

tetrahydroquinoline; synthesis; copper; swern oxidation; optically pure;

D O I：

10.1016/j.tetlet.2003.11.086

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Using a copper-catalyzed coupling reaction of amino acid and aryl halide, followed by intramolecular cyclization of N-aryl-1-hydroxyl-3-propylamines under the Swern's condition as the key steps, (S)-2-hydroxymethyl-1,2,3,4-tetrahydroquinoline was synthesized as an example of optically pure 2-functionalized 1,2,3,4-tetrahydroquinolines. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：1027 / 1029

页数：3

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