Association of eptifibatide and acute profound thrombocytopenia

被引:33
作者
Hongo, RH [1 ]
Brent, BN [1 ]
机构
[1] Calif Pacific Med Ctr, Div Cardiol, San Francisco, CA 94120 USA
关键词
D O I
10.1016/S0002-9149(01)01695-2
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Despite the absence of an association between eptifibatide and thrombocytopenia in clinical studies, we have described 4 cases of eptifibatide-associated acute profound thrombocytopenia in patients receiving eptifibatide with percutaneous coronary intervention. There is no indication that the number of eptifibatide boluses influences the incidence of thrombocytopenia, the incidence of acute profound thrombocytopenia. or the degree to which platelet counts decrease.
引用
收藏
页码:428 / +
页数:6
相关论文
共 19 条
[1]  
AMIRAL J, 1992, THROMB HAEMOSTASIS, V68, P95
[2]  
Arepally G, 1995, AM J CLIN PATHOL, V104, P648
[3]   Occurrence and clinical significance of thrombocytopenia in a population undergoing high-risk percutaneous coronary revascularization [J].
Berkowitz, SD ;
Sane, DC ;
Sigmon, KN ;
Shavender, JH ;
Harrington, RA ;
Tcheng, JE ;
Topol, EJ ;
Califf, RM .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1998, 32 (02) :311-319
[4]  
Berkowitz SD, 1997, CIRCULATION, V95, P809
[5]  
CHARO IF, 1992, CIRCULATION, V86, P260
[6]   A NEW-TYPE OF PSEUDOTHROMBOCYTOPENIA - EDTA-MEDIATED AGGLUTINATION OF PLATELETS BEARING FAB FRAGMENTS OF A CHIMERIC ANTIBODY [J].
CHRISTOPOULOS, CG ;
MACHIN, SJ .
BRITISH JOURNAL OF HAEMATOLOGY, 1994, 87 (03) :650-652
[7]   Thrombocytopenia with GP IIb/IIIa inhibitors: A meta-analysis [J].
Giugliano, RP ;
Hyatt, RR .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1998, 31 (02) :185A-185A
[8]   IMMEDIATE AND REVERSIBLE PLATELET INHIBITION AFTER INTRAVENOUS ADMINISTRATION OF A PEPTIDE GLYCOPROTEIN IIB/IIIA INHIBITOR DURING PERCUTANEOUS CORONARY INTERVENTION [J].
HARRINGTON, RA ;
KLEIMAN, NS ;
KOTTKEMARCHANT, K ;
LINCOFF, AM ;
TCHENG, JE ;
SIGMON, KN ;
JOSEPH, D ;
RIOS, G ;
TRAINOR, K ;
ROSE, D ;
GREENBERG, CS ;
KITT, MM ;
TOPOL, EJ ;
CALIFF, RM .
AMERICAN JOURNAL OF CARDIOLOGY, 1995, 76 (17) :1222-1227
[9]   Abciximab-associated profound thrombocytopenia: Therapy with immunoglobulin and platelet transfusion [J].
Kereiakes, DJ ;
Essell, JH ;
Abbottsmith, CW ;
Broderick, TM ;
Runyon, JP .
AMERICAN JOURNAL OF CARDIOLOGY, 1996, 78 (10) :1161-&
[10]   Clinical significance of thrombocytopenia during a non-ST-elevation acute coronary syndrome - The platelet glycoprotein IIb IIIa in unstable angina: Receptor suppression using integrilin therapy (PURSUIT) trial experience [J].
McClure, MW ;
Berkowitz, SD ;
Sparapani, R ;
Tuttle, R ;
Kleiman, NS ;
Berdan, LG ;
Lincoff, AM ;
Deckers, J ;
Diaz, R ;
Karsch, KR ;
Gretler, D ;
Kitt, M ;
Simoons, M ;
Topol, EJ ;
Califf, RM ;
Harrington, RA .
CIRCULATION, 1999, 99 (22) :2892-2900