Serum insulin-like growth factor 1 in congenital heart disease

被引：30

作者：

Barton, JS ^{[1
]}

Hindmarsh, PC ^{[1
]}

Preece, MA ^{[1
]}

机构：

[1] INST CHILD HLTH,MED UNIT,GROWTH RES CTR,LONDON,ENGLAND

来源：

ARCHIVES OF DISEASE IN CHILDHOOD | 1996年 / 75卷 / 02期

关键词：

congenital heart disease; insulin-like growth factor I; insulin-like growth factor binding protein-3;

D O I：

10.1136/adc.75.2.162

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Serum insulin-like growth factor 1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3), and a range of growth and nutritional variables were investigated in 62 infants with congenital heart disease and healthy controls. Infants with congenital heart disease were small, underweight, and had a reduced energy intake. Serum IGF-1 and IGFBP-3 concentrations were significantly reduced. Decreased IGF-1 and IGFBP-3 levels are observed in nutritional deficiency; similar findings in congenital heart disease suggest that undernutrition contributes to the poor growth of these infants. Serial measurements of serum IGF-1 and IGFBP-3 may be helpful in monitoring the effect of nutritional treatment in congenital heart disease.

引用

页码：162 / 163

页数：2

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