Correlates of Immunity to Filovirus Infection

被引：28

作者：

Bradfute, Steven B. ^{[1
]}

Bavari, Sina ^{[1
]}

机构：

[1] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA

来源：

VIRUSES-BASEL | 2011年 / 3卷 / 07期

关键词：

filovirus; ebola; marburg; immunity; EBOLA-VIRUS INFECTION; PROTECTS NONHUMAN-PRIMATES; MARBURG HEMORRHAGIC-FEVER; DOUBLE-STRANDED-RNA; T-CELL RESPONSES; MOUSE MODEL; POSTEXPOSURE PROTECTION; DENDRITIC CELLS; VP35; PROTEIN; EMERGENCY PROPHYLAXIS;

D O I：

10.3390/v3070982

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Filoviruses can cause severe, often fatal hemorrhagic fever in humans. Recent advances in vaccine and therapeutic drug development have provided encouraging data concerning treatment of these infections. However, relatively little is known about immune responses in fatal versus non-fatal filovirus infection. This review summarizes the published literature on correlates of immunity to filovirus infection, and highlights deficiencies in our knowledge on this topic. It is likely that there are several types of successful immune responses, depending on the type of filovirus, and the presence and timing of vaccination or drug treatment.

引用

页码：982 / 1000

页数：19

共 125 条

[1] Apoptosis in fatal Ebola infection. Does the virus toll the bell for immune system? [J].

Baize, S ;

Leroy, EM ;

Mavoungou, E ;

Fisher-Hoch, SP .

APOPTOSIS, 2000, 5 (01) :5-7

[2] Defective humoral responses and extensive intravascular apoptosis are associated with fatal outcome in Ebola virus-infected patients [J].

Baize, S ;

Leroy, EM ;

Georges-Courbot, MC ;

Capron, M ;

Lansoud-Soukate, J ;

Debré, P ;

Fisher-Hoch, SP ;

McCormick, JB ;

Georges, AJ .

NATURE MEDICINE, 1999, 5 (04) :423-426

[3] Inflammatory responses in Ebola virus-infected patients [J].

Baize, S ;

Leroy, EM ;

Georges, AJ ;

Georges-Courbot, MC ;

Capron, M ;

Bedjabaga, I ;

Lansoud-Soukate, J ;

Mavoungou, E .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2002, 128 (01) :163-168

[4] Discovery of Swine as a Host for the Reston ebolavirus [J].

Barrette, Roger W. ;

Metwally, Samia A. ;

Rowland, Jessica M. ;

Xu, Lizhe ;

Zaki, Sherif R. ;

Nichol, Stuart T. ;

Rollin, Pierre E. ;

Towner, Jonathan S. ;

Shieh, Wun-Ju ;

Batten, Brigid ;

Sealy, Tara K. ;

Carrillo, Consuelo ;

Moran, Karen E. ;

Bracht, Alexa J. ;

Mayr, Gregory A. ;

Sirios-Cruz, Magdalena ;

Catbagan, Davinio P. ;

Lautner, Elizabeth A. ;

Ksiazek, Thomas G. ;

White, William R. ;

McIntosh, Michael T. .

SCIENCE, 2009, 325 (5937) :204-206

[5]

Borisevich I. V, 2008, Voprosy Virusologii, V53, P39

[6]

Borisevich IV, 1995, VOP VIRUSOL+, V40, P270

[7] Ebola and Marburg viruses replicate in monocyte-derived dendritic cells without inducing the production of cytokines and full maturation [J].

Bosio, CM ;

Aman, MJ ;

Grogan, C ;

Hogan, R ;

Ruthel, G ;

Negley, D ;

Mohamadzadeh, M ;

Bavari, S ;

Schmaljohn, A .

JOURNAL OF INFECTIOUS DISEASES, 2003, 188 (11) :1630-1638

[8]

Bradfute SB, 2011, HUM VACCIN, V7

[9] Functional CD8+ T cell responses in lethal Ebola virus infection [J].

Bradfute, Steven B. ;

Warfield, Kelly L. ;

Bavari, Sina .

JOURNAL OF IMMUNOLOGY, 2008, 180 (06) :4058-4066

[10] Lymphocyte death in a mouse model of Ebola virus infection [J].

Bradfute, Steven B. ;

Braun, Denise R. ;

Shamblin, Joshua D. ;

Geisbert, Joan B. ;

Paragas, Jason ;

Garrison, Aura ;

Hensley, Lisa E. ;

Geisbert, Thomas W. .

JOURNAL OF INFECTIOUS DISEASES, 2007, 196 :S296-S304

← 1 2 3 4 5 6 7 8 9 10 →