A Paterno-Buchi approach to the synthesis of merrilactone A

被引：44

作者：

Iriondo-Alberdi, J ^{[1
]}

Perea-Buceta, JE ^{[1
]}

Greaney, MF ^{[1
]}

机构：

[1] Univ Edinburgh, Sch Chem, Edinburgh EH9 3JJ, Midlothian, Scotland

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 18期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1021/ol0514496

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A six-step approach to the tetracyclic core of merrilactone A is described that uses an intramolecular Paterno-BUchi photoaddition to install the key oxetane ring. Irradiation of bicyclic enone 16, constructed through cyclopentenone alkylation followed by a domino oxy-/carbopalladation reaction, produces the tetracyclic oxetane 17 in excellent yield, having the core carbon skeleton of the target compound merrilactone A.

引用

页码：3969 / 3971

页数：3

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