Ovarian androgens but not estrogens correlate with the degree of systemic inflammation observed during controlled ovarian hyperstimulation

被引:10
作者
Orvieto, R
Fisch, N
Yulzari-Roll, V
La Marca, A
机构
[1] Rabin Med Ctr, Dept Obstet & Gynecol, Petah Tiqwa, Israel
[2] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel
[3] Univ Modena, Dept Obstet & Gynecol, I-41100 Modena, Italy
关键词
androgens; C-reactive protein; controlled ovarian hyperstimulation; in-vitro fertilization; ovarian hyperstimulation syndrome;
D O I
10.1080/09513590500279667
中图分类号
R5 [内科学];
学科分类号
1002 [临床医学]; 100201 [内科学];
摘要
Aim. To investigate the behavior and association of serum androgen and serum C-reactive protein (CRP) in patients undergoing controlled ovarian hyperstimulation (COH) for in vitro fertilization (IVF). Design. Prospective, observational study. Setting. An IVF unit of an academic medical center. Patients and methods. Blood was drawn three times during the COH cycle from 15 patients undergoing the long gonadotropin-releasing hormone-analog protocol: the day on which adequate suppression was obtained (Day-S); the day of or prior to administration of human chorionic gonadotropin (Day-hCG); and the day of ovum pick-up (Day-OPU). Levels of sex steroids and serum CRP were compared among the three time points. Results. There was a significant increase in serum ovarian androgen levels during gonadotropin treatment. After hCG administration, there was a significant increase in the levels of both serum CRP and ovarian androgens (testosterone, androstenedione), with no significant change in adrenal androgen (dehydroepiandrosterone). Significant correlations were observed between CRP and ovarian androgen levels but not with dehydroepiandrosterone sulfate or estradiol levels. Conclusion. In patients undergoing COH for IVF, ovarian androgen levels increase in correlation with the degree of inflammation, as reflected by CRP levels. Further studies are necessary to elucidate whether androgens play a role in or are predictive of the systemic inflammatory response in COH.
引用
收藏
页码:170 / 173
页数:4
相关论文
共 25 条
[1]
The levels of C-reactive protein in women treated by IVF [J].
Almagor, M ;
Hazav, A ;
Yaffe, H .
HUMAN REPRODUCTION, 2004, 19 (01) :104-106
[2]
CASPER RF, 1984, FERTIL STERIL, V42, P39
[3]
CASTRACANE VD, 1983, FERTIL STERIL, V39, P553
[4]
CEDARS MI, 1990, FERTIL STERIL, V53, P627
[5]
PHYSIOPATHOLOGY OF PREMATURE PROGESTERONE ELEVATION [J].
FANCHIN, R ;
DEZIEGLER, D ;
CASTRACANE, VD ;
TAIEB, J ;
OLIVENNES, F ;
FRYDMAN, R .
FERTILITY AND STERILITY, 1995, 64 (04) :796-801
[6]
Premature plasma progesterone and androgen elevation are not prevented by adrenal suppression in in vitro fertilization [J].
Fanchin, R ;
Righini, C ;
Olivennes, F ;
Taieb, J ;
deZiegler, D ;
Frydman, R .
FERTILITY AND STERILITY, 1997, 67 (01) :115-119
[7]
Human chorionic gonadotropin administration does not increase plasma androgen levels in patients undergoing controlled ovarian hyperstimulation [J].
Fanchin, R ;
de Ziegler, D ;
Taieb, J ;
Olivennes, F ;
Castracane, VD ;
Frydman, R .
FERTILITY AND STERILITY, 2000, 73 (02) :275-279
[8]
Low grade chronic inflammation in women with polycystic ovarian syndrome [J].
Kelly, CCJ ;
Lyall, H ;
Petrie, JR ;
Gould, GW ;
Connell, JMC ;
Sattar, N .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (06) :2453-2455
[9]
INDUCTION OF OVULATION WITH MENOTROPINS IN WOMEN WITH POLYCYSTIC OVARY SYNDROME [J].
KEMMANN, E ;
TAVAKOLI, F ;
SHELDEN, RM ;
JONES, JR .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1981, 141 (01) :58-64
[10]
Androgens and cardiovascular disease [J].
Liu, PY ;
Death, AK ;
Handelsman, DJ .
ENDOCRINE REVIEWS, 2003, 24 (03) :313-340