Familial occurrence of tardive dyskinesia

被引:72
作者
Müller, DJ
Schulze, TG
Knapp, M
Held, T
Krauss, H
Weber, T
Ahle, G
Maroldt, A
Alfter, D
Maier, W
Nöthen, MM
Rietschel, M
机构
[1] Univ Bonn, Dept Psychiat, D-53105 Bonn, Germany
[2] Univ Bonn, Inst Med Biometry Informat & Epidemiol, D-5300 Bonn, Germany
[3] Mental State Hosp, Rhein Kliniken, Bonn, Germany
[4] Univ Bonn, Inst Human Genet, D-5300 Bonn, Germany
关键词
dyskinesias; risk factors; genetics;
D O I
10.1034/j.1600-0447.2001.00401.x
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Objective: Familial occurrence of tardive dyskinesia (TD) and schizophrenia has been hypothesized to confer risk to the development of TD. We investigated these hypotheses in a large patient sample applying standardized methods for phenotype characterization. Method: Two hundred and twenty-two patients with a diagnosis of schizophrenia or schizoaffective disorder were assessed for TD and for family history of schizophrenia or schizoaffective disorder. Thirty-nine patients had 40 affected first-degree family members, one patient having two first-degree relatives. Of these, 17 pairs and one triplet were personally examined. Results: 1) There was a tendency for TD in the affected relatives to be associated with the TD status of the index-patient; this finding was unrelated to age and doses of neuroleptic medication. 2) No association between a family history of schizophrenia or schizoaffective disorder and TD was found. Conclusion: A family history of TD might represent a risk factor for TD, whereas a family history of schizophrenia does not.
引用
收藏
页码:375 / 379
页数:5
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