Effect of ginseng saponins on β-amyloid-suppressed acetylcholine release from rat hippocampal slices

被引:38
作者
Lee, TF
Shiao, YJ
Chen, CF
Wang, LCH
机构
[1] Univ Alberta, Dept Sci Biol, Edmonton, AB T6G 2E9, Canada
[2] Natl Yang Ming Med Coll, Inst Pharmacol, Taipei 11221, Taiwan
关键词
Panax quinquefolius L; Araliaceae; ginsenosides; beta-amyloid; acetylcholine release; hippocampus;
D O I
10.1055/s-2001-17366
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
In view of the facts that ginseng has been shown to improve age-related memory deficits and beta -amyloid-related peptides have been suggested to play a significant role in memory degeneration in the elderly, the present study was carried out to examine the effect of various ginsenosides on beta -amyloid peptides-modulated acetylcholine (ACh) release, a key neurotransmitter in memory processing, from the hippocampal slices. Addition of beta -amyloid fragment(25-35) (0.01-1 muM) in the superfusion medium suppressed the K+-evoked [H-3]-ACh release from the rat hippocampal slices in a concentration-related manner and about 40% reduction in ACh outflow was observed when incubating with the highest concentration of an amyloid fragment (1 muM). Inclusion of the ginsenoside components Rb-1 (0.1 muM), but not Rg(1), caused a rightward shift of the concentration-response curve of beta -amyloid. The reversal of the beta -amyloid-inhibited ACh release by Rb-1 was not blocked by tetrodotoxin (1 muM) indicating that an interaction occurs at the cholinergic synapse. These results suggest that Rb-1 may elicit its anti-amnesic effect by minimizing the inhibitory effect of beta -amyloid peptides.
引用
收藏
页码:634 / 637
页数:4
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