Maternal Vitamin D Deficiency During Pregnancy Elevates the Risks of Small for Gestational Age and Low Birth Weight Infants in Chinese Population

被引：170

作者：

Chen, Yuan-Hua ^{[1
,2
,3
]}

Fu, Lin ^{[1
]}

Hao, Jia-Hu ^{[1
,2
]}

Yu, Zhen ^{[1
]}

Zhu, Peng ^{[1
,2
]}

Wang, Hua ^{[1
]}

Xu, Yuan-Yuan ^{[1
,2
]}

Zhang, Cheng ^{[1
,2
]}

Tao, Fang-Biao ^{[1
,2
]}

Xu, De-Xiang ^{[1
,2
]}

机构：

[1] Anhui Med Univ, Sch Publ Hlth, Hefei 230032, Peoples R China

[2] Anhui Med Univ, Anhui Prov Key Lab Populat Hlth & Aristogen, Hefei 230032, Peoples R China

[3] Anhui Med Univ, Sch Basic Med Sci, Hefei 230032, Peoples R China

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 2015年 / 100卷 / 05期

基金：

中国国家自然科学基金;

关键词：

SERUM 25-HYDROXYVITAMIN D; FETAL-GROWTH RESTRICTION; NECROSIS-FACTOR-ALPHA; 1ST TRIMESTER; INSUFFICIENCY; INFLAMMATION; RETARDATION; NEWBORN; ADULTS;

D O I：

10.1210/jc.2014-4407

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Context: Vitamin D deficiency is common in pregnant women. Nevertheless, the association between maternal vitamin D status during pregnancy and the risk of having small for gestational age (SGA) and low birth weight (LBW) infants is uncertain. Objective: The objective of this study was to investigate whether there is a correlation between maternal vitamin D deficiency during pregnancy and the risk of having SGA and LBW infants in a Chinese population. Design and Participants: This was a population-based birth cohort study that recruited 3658 eligible mother-and-singleton-offspring pairs. Main Outcome Measures: Serum 25-hydroxyvitamin D was measured by RIA. The rate and relative risk (RR) for SGA and LBW infants were calculated among subjects with vitamin D deficiency and insufficiency during pregnancy. Results: There was a positive correlation between maternal serum 25-hydroxyvitamin D level and offspring birth weight (r = 0.477; P < .001). Further analysis showed that 4.98% of neonates were LBW infants among the subjects with vitamin D deficiency (RR, 12.00; 95% confidence interval [CI], 4.37, 33.00) and 1.32% among the subjects with vitamin D insufficiency (RR, 3.18; 95% CI, 1.07, 9.48). After adjustment for confounders, the RR for LBW infants was 12.31 (95% CI, 4.47, 33.89) among subjects with vitamin D deficiency and 3.15 (95% CI, 1.06, 9.39) among subjects with vitamin D insufficiency. Moreover, 16.01% of neonates were SGA infants among subjects with vitamin D deficiency (RR, 5.72; 95% CI, 3.80, 8.59) and 5.59% among subjects with vitamin D insufficiency (RR, 1.99; 95% CI, 1.27, 3.13). After adjustment for confounders, the RR for SGA infants was 6.47 (95% CI, 4.30, 9.75) among subjects with vitamin D deficiency and 2.01(95% CI, 1.28, 3.16) among subjects with vitamin D insufficiency. Conclusion: Maternal vitamin D deficiency during pregnancy elevates the risk of SGA and LBW infants in a Chinese population.

引用

页码：1912 / 1919

页数：8

共 38 条

[1]

Vitamin D increases circulating IGF1 in adults: potential implication for the treatment of GH deficiency [J].