Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation

被引：1940

作者：

Belanger, Mireille ^{[1
]}

Allaman, Igor ^{[1
]}

Magistretti, Pierre J. ^{[1
,2
]}

机构：

[1] Ecole Polytech Fed Lausanne, Brain Mind Inst, Lab Neuroenerget & Cellular Dynam, CH-1015 Lausanne, Switzerland

[2] CHUV, Ctr Neurosci Psychiat, Dept Psychiat, CH-1008 Prilly, Switzerland

来源：

CELL METABOLISM | 2011年 / 14卷 / 06期

基金：

瑞士国家科学基金会;

关键词：

VASOACTIVE INTESTINAL POLYPEPTIDE; CEREBRAL-BLOOD-FLOW; LACTATE-SHUTTLE; NITRIC-OXIDE; RAT-BRAIN; SENSORY STIMULATION; GLUCOSE-UTILIZATION; IN-VITRO; OXIDATIVE-METABOLISM; AEROBIC GLYCOLYSIS;

D O I：

10.1016/j.cmet.2011.08.016

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The energy requirements of the brain are very high, and tight regulatory mechanisms operate to ensure adequate spatial and temporal delivery of energy substrates in register with neuronal activity. Astrocytes a type of glial cell have emerged as active players in brain energy delivery, production, utilization, and storage. Our understanding of neuroenergetics is rapidly evolving from a "neurocentric" view to a more integrated picture involving an intense cooperativity between astrocytes and neurons. This review focuses on the cellular aspects of brain energy metabolism, with a particular emphasis on the metabolic interactions between neurons and astrocytes.

引用

页码：724 / 738

页数：15

共 130 条

[1]

Dynamic imaging of free cytosolic ATP concentration during fuel sensing by rat hypothalamic neurones:: evidence for ATP-independent control of ATP-sensitive K+ channels [J].