Two new lignans, interiotherins A and B, as anti-HIV principles from Kadsura interior

被引：120

作者：

Chen, DF

Zhang, SX

Chen, K

Zhou, BN

Wang, P

Cosentino, LM

Lee, KH

机构：

[1] SHANGHAI MED UNIV, SCH PHARM, DEPT PHARMACOGNOSY, SHANGHAI 200032, PEOPLES R CHINA

[2] UNIV N CAROLINA, SCH PHARM, DIV MED CHEM & NAT PROD, NAT PROD LAB, CHAPEL HILL, NC 27599 USA

[3] ACAD SINICA, SHANGHAI INST MAT MED, SHANGHAI 200031, PEOPLES R CHINA

[4] BIOTECH RES LABS INC, ROCKVILLE, MD 20850 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 1996年 / 59卷 / 11期

关键词：

D O I：

10.1021/np9601667

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new lignans, interiotherins A (1) and B (2), along with two known lignans, angeloylgomisin R (3) and schisantherin D (4), were isolated from Kadsura interior. Their structures and stereochemistries were determined from spectral data, Compounds 1 and 4 inhibit HIV replication with EC(50) values of 3.1 and 0.5 mu g/mL, respectively.

引用

页码：1066 / 1068

页数：3

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