Onset of dementia is associated with apolipoprotein E epsilon 4 in Down's syndrome

被引：80

作者：

Schupf, N

Kapell, D

Lee, JH

Zigman, W

Canto, B

Tycko, B

Mayeux, R

机构：

[1] NEW YORK STATE INST BASIC RES DEV DISABIL,LAB COMMUNITY PSYCHOL,STATEN ISL,NY 10314

[2] COLUMBIA UNIV,SCH PUBL HLTH,DIV EPIDEMIOL,NEW YORK,NY

[3] COLUMBIA UNIV,COLL PHYS & SURG,DEPT NEUROL,NEW YORK,NY

[4] COLUMBIA UNIV,COLL PHYS & SURG,DEPT PSYCHIAT,NEW YORK,NY

[5] COLUMBIA UNIV,GERTRUDE H SERGIEVSKY CTR,NEW YORK,NY

[6] COLUMBIA UNIV,DEPT PATHOL,NEW YORK,NY

来源：

ANNALS OF NEUROLOGY | 1996年 / 40卷 / 05期

关键词：

D O I：

10.1002/ana.410400518

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We examined the influence of apolipoprotein E (apoE) genotype on risk of dementia in 82 adults with Down's syndrome (DS). Compared with those with an apoE 3/3 genotype, the group of adults with DS with apoE 2/4, 3/4, and 4/4 genotypes were 5 times more likely to become demented (RR = 4.7; 95% CI = 1.2, 17.9). We hypothesize that the increased risk of dementia may be mediated by exacerbation of beta-amyloid deposition.

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页码：799 / 801

页数：3

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