Incidental findings in human subjects research: What do investigators owe research participants?

被引:79
作者
Miller, Franklin G.
Mello, Michelle M. [1 ]
Joffe, Steven [2 ,3 ,4 ]
机构
[1] Harvard Univ, Sch Publ Hlth, Cambridge, MA 02138 USA
[2] Harvard Univ, Sch Med, Cambridge, MA 02138 USA
[3] Dana Farber Canc Inst, Boston, MA 02115 USA
[4] Childrens Hosp, Boston, MA 02115 USA
关键词
D O I
10.1111/j.1748-720X.2008.00269.x
中图分类号
B82 [伦理学(道德学)];
学科分类号
摘要
The use of brain imaging technology as a common tool of research has spawned concern and debate over how investigators should respond to incidental findings discovered in the course of research. In this article, we argue that investigators have an obligation to respond to incidental findings in view of their entering into a professional relationship with research participants in which they are granted privileged access to private information with potential relevance to participants' health. We discuss the scope and limits of this professional obligation to respond to incidental findings, bearing in mind that the relationship between investigators and research participants differs fundamentally from the doctor-patient relationship.
引用
收藏
页码:271 / 279
页数:9
相关论文
共 17 条
[1]  
APPELBAUM PS, HASTINGS
[2]  
Beauchamp TL., 1983, Principles of biomedical ethics, V2
[3]   Medical researchers' ancillary clinical care responsibilities [J].
Belsky, L ;
Richardson, HS .
BRITISH MEDICAL JOURNAL, 2004, 328 (7454) :1494-1496
[4]   Prevalence of adrenal incidentaloma in a contemporary computerized tomography series [J].
Bovio, S. ;
Cataldi, A. ;
Reimondo, G. ;
Sperone, P. ;
Novello, S. ;
Berruti, A. ;
Borasio, P. ;
Fava, C. ;
Dogliotti, L. ;
Scagliotti, G. V. ;
Angeli, A. ;
Terzolo, M. .
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2006, 29 (04) :298-302
[5]   Incidental research imaging findings - Pandora's costly box [J].
Grossman, RI ;
Bernat, JL .
NEUROLOGY, 2004, 62 (06) :849-850
[6]   Ethics - Incidental findings in brain imaging research [J].
Illes, J ;
Kirschen, MP ;
Edwards, E ;
Stanford, LR ;
Bandettini, P ;
Cho, MK ;
Ford, PJ ;
Glover, GH ;
Kulynych, J ;
Macklin, R ;
Michael, DB ;
Wolf, SM .
SCIENCE, 2006, 311 (5762) :783-784
[7]   Discovery and disclosure of incidental findings in neuroimaging research [J].
Illes, J ;
Kirschen, MP ;
Karetsky, K ;
Kelly, M ;
Saha, A ;
Desmond, JE ;
Raffin, TA ;
Glover, GH ;
Atlas, SW .
JOURNAL OF MAGNETIC RESONANCE IMAGING, 2004, 20 (05) :743-747
[8]   Ethical and practical considerations in managing incidental findings in functional magnetic resonance imaging [J].
Illes, J ;
Desmond, JE ;
Huang, LF ;
Raffin, TA ;
Atlas, SW .
BRAIN AND COGNITION, 2002, 50 (03) :358-365
[9]   Subjects' expectations in neuroimaging research [J].
Kirschen, MP ;
Jaworska, A ;
Illes, J .
JOURNAL OF MAGNETIC RESONANCE IMAGING, 2006, 23 (02) :205-209
[10]   Incidental neuroimaging findings: lessons from brain research in volunteers [J].
Kleinschmidt, Andreas .
CURRENT OPINION IN NEUROLOGY, 2007, 20 (04) :387-389