The laminins: Role in intestinal morphogenesis and differentiation

被引：70

作者：

Simon-Assmann, P ^{[1
]}

Lefebvre, O ^{[1
]}

Bellissent-Waydelich, A ^{[1
]}

Olsen, J ^{[1
]}

Orian-Rousseau, V ^{[1
]}

De Arcangelis, A ^{[1
]}

机构：

[1] INSERM U381, F-67200 Strasbourg, France

来源：

INTESTINAL PLASTICITY IN HEALTH AND DISEASE | 1998年 / 859卷

关键词：

D O I：

10.1111/j.1749-6632.1998.tb11110.x

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Dynamic and reciprocal heterotypic cell interactions are crucial for intestinal morphogenesis and differentiation. This paper emphasizes the role of basement membrane molecules and in particular of laminins as potent mediators in this intercellular cross talk. Changes in the expression or localization of laminin isoforms or of integrins during development and cell migration strengthen the concept that heterogeneity in cell-matrix interactions could mediate distinct cell responses. A combination of genetic or biochemical approaches associated with in vitro models allows us to study the potential role of each laminin isoform in basement membrane assembly, cell migration, or cell differentiation.

引用

页码：46 / 64

页数：19

共 69 条

[1] RECIPROCAL EXPRESSION OF LAMININ A-CHAIN ISOFORMS ALONG THE CRYPT-VILLUS AXIS IN THE HUMAN SMALL-INTESTINE [J].