Activities of cethromycin and telithromycin against recent North American isolates of Streptococcus pneumoniae

被引:16
作者
Jorgensen, JH
Crawford, SA
McElmeel, ML
Whitney, CG
机构
[1] Univ Texas, Hlth Sci Ctr, Dept Pathol, San Antonio, TX 78229 USA
[2] Ctr Dis Control & Prevent, Div Bacterial & Mycot Dis, Natl Ctr Infect Dis, Atlanta, GA USA
关键词
D O I
10.1128/AAC.48.2.605-607.2004
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The in vitro activities of two investigational ketolides, cethromycin (formerly ABT-773) and telithromycin, were determined for a selected group of 312 Streptococcus pneumoniae isolates from a national surveillance program. The MIC of cethromycin at which 50% of the isolates were inhibited was 0.008 mug/ml, and the MIC at which 90% of the isolates were inhibited was 0.06 mug/ml; the corresponding values for telithromycin were less than or equal to0.015 and 0.25 mug/ml, respectively. For six quinupristin-dalfopristin-resistant strains, the cethromycin MICs were 0.25 to 16 mug/ml and the telithromycin MICs were 1 to 4 mug/ml. However, there was only 0.3% resistance to telithromycin.
引用
收藏
页码:605 / 607
页数:3
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