The role of age in neuroblastoma risk stratification: the German, Italian, and children's oncology group perspectives

被引：38

作者：

London, WB

Boni, L

Simon, T

Berthold, F

Twist, C

Schmidt, ML

Castleberry, RP

Matthay, KK

Cohn, SL

De Bernardi, B

机构：

[1] Univ Florida, Gainesville, FL 32601 USA

[2] Dept Stat, Childrens Oncol Grp, Gainesville, FL 32601 USA

[3] Natl Inst Canc Res, Core Facil Clin Trials, Genoa, Italy

[4] Univ Cologne, Childrens Hosp, Cologne, Germany

[5] Stanford Univ, Med Ctr, Palo Alto, CA 94304 USA

[6] Univ Illinois, Chicago, IL USA

[7] Univ Alabama, Childrens Hosp, Birmingham, AL USA

[8] Univ Calif San Francisco, Sch Med, San Francisco, CA 94143 USA

[9] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA

来源：

CANCER LETTERS | 2005年 / 228卷 / 1-2期

关键词：

neuroblastoma; risk factors; age; prognosis;

D O I：

10.1016/j.canlet.2004.12.054

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent evidence suggests that the cut-off for age utilized in neuroblastoma risk groups should be increased from the 365-day cutoff currently in use. Separate cooperative group analyses were performed by German and Italian groups and two analyses by the Children's Oncology Group (North America, Australia, New Zealand, Switzerland, Netherlands). In general, the results are in agreement regarding the prognostic contribution of age. There is strong evidence to support an increase in the age cut-off to a value in the range of 15-18 months based on the results from the German analysis and two COG analyses. However, Italian results in INSS stage 4 patients show that outcome in patients 12-17 months is not better than that of older patients. Further analyses are warrented. (C) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：257 / 266

页数：10

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