Fgf8 drives myogenic progression of a novel lateral fast muscle fibre population in zebrafish

被引:109
作者
Groves, JA
Hammond, CL
Hughes, SM [1 ]
机构
[1] Kings Coll London, MRC, Ctr Dev Neurobiol, London SE1 1UL, England
[2] Kings Coll London, Randall Div Cell & Mol Biophys, London SE1 1UL, England
来源
DEVELOPMENT | 2005年 / 132卷 / 19期
基金
英国医学研究理事会;
关键词
fibroblast growth factor 8; muscle; zebrafish; fast; myod; somite;
D O I
10.1242/dev.01958
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Fibroblast growth factors (Fgfs) have long been implicated in regulating vertebrate skeletal muscle differentiation, but their precise role(s) in vivo remain unclear. Here, we show that Fgf8 signalling in the somite is required for myod expression and terminal differentiation of a subset of fast muscle cells in the zebrafish lateral somite. In the absence of Fgf8, lateral somite cells transiently express myf5 but fail to make muscle and remain in a dermomyotome-like state characterised by pax3 and meox expression. Slow muscle fibres form and commence normal migration in the absence of Fgf8, but fail to traverse the expanded undifferentiated lateral somite. The Fgf8-independent residual population of medial fast muscle fibres is not Hedgehog dependent. However, Fgf8-independent medial fast muscle precursors are lacking in floatinghead mutants, suggesting that they require another ventral midline-derived signal. We conclude that Fgf8 drives terminal differentiation of a specific population of lateral muscle precursor cells within the early somite.
引用
收藏
页码:4211 / 4222
页数:12
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