Oxidatively generated complex DNA damage: Tandem and clustered lesions

被引：208

作者：

Cadet, Jean ^{[1
,2
]}

Ravanat, Jean-Luc ^{[1
]}

TavernaPorro, Marisa ^{[1
]}

Menoni, Herve ^{[3
,4
]}

Angelov, Dimitar ^{[3
]}

机构：

[1] CEA Grenoble, Lab Les Acides Nucl, Inst Nanosci & Cryogenie, SCIB UMR E CEA UJF 3, F-38054 Grenoble 9, France

[2] Univ Sherbrooke, Dept Med Nucl & Radiobiol, Fac Med Sci Sante, Sherbrooke, PQ J1H 5N4, Canada

[3] Ecole Normale Super Lyon, Lab Biol Mol Cellule, UMR CNRS 5239, F-69364 Lyon 07, France

[4] Erasmus MC, Dept Genet, Rotterdam, Netherlands

来源：

CANCER LETTERS | 2012年 / 327卷 / 1-2期

关键词：

Oxidative stress; Ionizing radiation; DNA single and double strand breaks; Purine; 5; 8-cyclonucleosides; Intrastrand cross-links; Interstrand cross-links; Tandem base lesions; DNA repair; Mutagenesis; PROTEIN CROSS-LINKS; BASE-EXCISION-REPAIR; IN-VITRO REPLICATION; DOUBLE-STRAND BREAKS; ONE-ELECTRON OXIDATION; HUMAN CELL-EXTRACTS; NF-KAPPA-B; NUCLEOTIDE EXCISION; GUANINE OXIDATION; CYTOTOXIC PROPERTIES;

D O I：

10.1016/j.canlet.2012.04.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

There is an increasing interest for oxidatively generated complex lesions that are potentially more detrimental than single oxidized nucleobases. In this survey, the recently available information on the formation and processing of several classes of complex DNA damage formed upon one radical hit including mostly hydroxyl radical and one-electron oxidants is critically reviewed. The modifications include tandem base lesions. DNA-protein cross-links and intrastrand (purine 5',8-cyclonucleosides, adjacent base cross-links) and interstrand cross-links. Information is also provided on clustered lesions produced essentially by exposure of cells to ionizing radiation and high energetic heavy ions through the involvement of multiple radical events that induce several lesions DNA in a close spatial vicinity. These consist mainly of double strand breaks (DSBs) and non-DSB clustered lesions that are referred as to oxidatively generated clustered DNA lesions (OCDLs). (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：5 / 15

页数：11

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