Synthesis of squamostanal-A

被引：5

作者：

Konno, H ^{[1
]}

Makabe, H ^{[1
]}

Tanaka, A ^{[1
]}

Oritani, T ^{[1
]}

机构：

[1] TOHOKU UNIV, GRAD SCH AGR, DIV ENVIRONM BIOREMEDIAT, AOBA KU, SENDAI, MIYAGI 981, JAPAN

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1996年 / 60卷 / 03期

关键词：

annonaceous acetogenins; oxidative cleavage;

D O I：

10.1271/bbb.60.526

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The first synthesis of squamostanal-A (1), separated as a degradation product of tetrahydrofuranic acetogenins, is described. Iodide 7, which corresponds to the latent aldehyde moiety of 1, was prepared through a 2-step sequence from 13-[tetrahydropyran-2'-yloxy]-2-tridecyn-1-ol (5). The NaHMDS-based coupling reaction of 7 with gamma-lactone 8 gave compound 9, which by a 3-step sequence, was coverted to 1.

引用

页码：526 / 527

页数：2

共 12 条

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