Dual regulation of the LDL receptor - Some clarity and new questions

被引：79

作者：

Attie, AD ^{[1
]}

Seidah, NG

机构：

[1] Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA

[2] Clin Res Inst Montreal, Biochem Neuroendocrinol Lab, Montreal, PQ H2W 1R7, Canada

来源：

CELL METABOLISM | 2005年 / 1卷 / 05期

关键词：

D O I：

10.1016/j.cmet.2005.04.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Upregulation of the expression of the LDL receptor (LDLR) gene does not always lead to an increase in the LDLR protein. While the mRNA expression of the LDLR and the newly studied proprotein convertase PCSK9 are coordinately upregulated in absence of sterols, the latter proteinase apparently enhances the degradation of the LDLR protein.

引用

收藏

页码：290 / 292

页数：3

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