Dopamine D3 receptor partial agonists and antagonists as potential drug abuse therapeutic agents

被引：171

作者：

Newman, AH

Grundt, P

Nader, MA

机构：

[1] NIDA, Med Chem Sect, Intramural Res Program, NIH, Baltimore, MD 21224 USA

[2] Wake Forest Univ, Sch Med, Dept Physiol Pharmacol & Radiol, Winston Salem, NC 27157 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2005年 / 48卷 / 11期

关键词：

D O I：

10.1021/jm040190e

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：3663 / 3679

页数：17

共 112 条

[1] A targeted mutation of the D-3 dopamine receptor gene is associated with hyperactivity in mice [J].

Accili, D ;

Fishburn, CS ;

Drago, J ;

Steiner, H ;

Lachowicz, JE ;

Park, BH ;

Gauda, EB ;

Lee, EJ ;

Cool, MH ;

Sibley, DR ;

Gerfen, CR ;

Westphal, H ;

Fuchs, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (05) :1945-1949

[2] Selective antagonism at dopamine D3 receptors prevents nicotine-triggered relapse to nicotine-seeking behavior [J].

Andreoli, M ;

Tessari, M ;

Pilla, M ;

Valerio, E ;

Hagan, JJ ;

Heidbreder, CA .

NEUROPSYCHOPHARMACOLOGY, 2003, 28 (07) :1272-1280

[3] Acute administration of the selective D3 receptor antagonist SB-277011A blocks the acquisition and expression of the conditioned place preference response to heroin in male rats [J].

Ashby, CR ;

Paul, M ;

Gardner, EL ;

Heidbreder, CA ;

Hagan, JJ .

SYNAPSE, 2003, 48 (03) :154-156

[4] A dopamine D3 receptor partial agonist blocks the expression of conditioned activity [J].

Aujla, H ;

Sokoloff, P ;

Beninger, RJ .

NEUROREPORT, 2002, 13 (01) :173-176

[5] Novel 2,3,4,5-tetrahydro-1H-3-benzazepines with high affinity and selectivity for the dopamine D3 receptor [J].

Austin, NE ;

Avenell, KY ;

Boyfield, I ;

Branch, CL ;

Hadley, MS ;

Jeffrey, P ;

Johnson, CN ;

Macdonald, GJ ;

Nash, DJ ;

Riley, GJ ;

Smith, AB ;

Stemp, G ;

Thewlis, KM ;

Vong, AKK ;

Wood, M .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (22) :2553-2555

[6] Pharmacokinetics of the novel, high-affinity and selective dopamine D3 receptor antagonist SB-277011 in rat, dog and monkey:: in vitro/in vivo correlation and the role of aldehyde oxidase [J].

Austin, NE ;

Baldwin, SJ ;

Cutler, L ;

Deeks, N ;

Kelly, PJ ;

Nash, M ;

Shardlow, CE ;

Stemp, G ;

Thewlis, K ;

Ayrton, A ;

Jeffrey, P .

XENOBIOTICA, 2001, 31 (8-9) :677-686

[7] The D3R partial agonist, BP 897, attenuates the discriminative stimulus effects of cocaine and D-amphetamine and is not self-administered [J].

Beardsley, PM ;

Sokoloff, P ;

Balster, RL ;

Schwartz, JC .

BEHAVIOURAL PHARMACOLOGY, 2001, 12 (01) :1-11

[8] Interactive SAR studies:: Rational discovery of super-potent and highly selective dopamine D3 receptor antagonists and partial agonists [J].

Bettinetti, L ;

Schlotter, K ;

Hübner, H ;

Gmeiner, P .

JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (21) :4594-4597

[9] Enhancement of ethanol reward by dopamine D3 receptor blockade [J].

Boyce, JM ;

Risinger, FO .

BRAIN RESEARCH, 2000, 880 (1-2) :202-206

[10] MODULATION OF COCAINE SELF-ADMINISTRATION IN THE RAT THROUGH D-3 DOPAMINE-RECEPTORS [J].

CAINE, SB ;

KOOB, GF .

SCIENCE, 1993, 260 (5115) :1814-1816

← 1 2 3 4 5 6 7 8 9 10 →