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Antigens of Mycobacterium tuberculosis recognized by antibodies during incipient, subclinical tuberculosis

被引：58
作者：
Singh, KK
Dong, YX
Belisle, JT
Harder, J
Arora, VK
Laal, S
机构：
[1] NYU, Sch Med, Dept Pathol, New York, NY USA
[2] New York Harbor Hlth Care Syst, New York, NY USA
[3] Colorado State Univ, Dept Microbiol Immunol & Parasitol, Mycobacteria Res Labs, Ft Collins, CO 80523 USA
[4] Lala Ram Sarup Inst TB & Resp Dis, New Delhi, India
来源：
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY | 2005年 / 12卷 / 02期
关键词：
D O I：
10.1128/CDLI.12.2.354-358.2005
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Serum samples obtained from human immunodeficiency virus (HIV)-infected tuberculosis (TB) patients months prior to clinical TB were used to delineate the profile of Mycobacterium tuberculosis culture filtrate proteins recognized during subclinical TB. A subset of similar to 12 antigens was recognized by antibodies in these serum samples. Antibodies to two of these antigens (81 [88]-kDa malate synthase [GlcB] and MPT51) were present in serum samples obtained during incipient subclinical TB in 19 (similar to 90%) of the 21 HIV-infected TB patients tested. These antigens will be useful for devising diagnostic tests that can identify HIV-positive individuals who are at a high risk for developing clinical TB.
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收藏
页码：354 / 358
页数：5
相关论文
共 21 条
[1]  
Ansari NA, 2002, INT J TUBERC LUNG D, V6, P55
[2]   HIV/AIDS: India's many epidemics [J].
Cohen, J .
SCIENCE, 2004, 304 (5670) :504-509
[3]   The growing burden of tuberculosis - Global trends and interactions with the HIV epidemic [J].
Corbett, EL ;
Watt, CJ ;
Walker, N ;
Maher, D ;
Williams, BG ;
Raviglione, MC ;
Dye, C .
ARCHIVES OF INTERNAL MEDICINE, 2003, 163 (09) :1009-1021
[4]  
Doherty TM, 2002, J CLIN MICROBIOL, V40, P704, DOI 10.1128/JCM.40.2.704-706.2002
[5]   Preventing opportunistic infections among human immunodeficiency virus-infected adults in African countries [J].
Grant, AD ;
Kaplan, JE ;
De Cock, KM .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2001, 65 (06) :810-821
[6]   Deaths from tuberculosis in sub-Saharan African countries with a high prevalence of HIV-1 [J].
Harries, AD ;
Hargreaves, NJ ;
Kemp, J ;
Jindani, A ;
Enarson, DA ;
Maher, D ;
Salaniponi, FM .
LANCET, 2001, 357 (9267) :1519-1523
[7]  
Hendrickson RC, 2000, J CLIN MICROBIOL, V38, P2354
[8]   Review of human immunodeficiency virus type 1-related opportunistic infections in sub-Saharan Africa [J].
Holmes, CB ;
Losina, E ;
Walensky, RP ;
Yazdanpanah, Y ;
Freedberg, KA .
CLINICAL INFECTIOUS DISEASES, 2003, 36 (05) :652-662
[9]   Duration of efficacy of treatment of latent tuberculosis infection in HIV infected adults [J].
Johnson, JL ;
Okwera, A ;
Hom, DL ;
Mayanja, H ;
Kityo, CM ;
Nsubuga, P ;
Nakibali, JG ;
Loughlin, AM ;
Yun, H ;
Mugyenyi, PN ;
Vernon, A ;
Mugerwa, RD ;
Ellner, JJ ;
Whalen, CC .
AIDS, 2001, 15 (16) :2137-2147
[10]   Surrogate marker of preclinical tuberculosis in human immunodeficiency virus infection: Antibodies to an 88-kDa secreted antigen of Mycobacterium tuberculosis [J].
Laal, S ;
Samanich, KM ;
Sonnenberg, MG ;
Belisle, JT ;
OLeary, J ;
Simberkoff, MS ;
ZollaPazner, S .
JOURNAL OF INFECTIOUS DISEASES, 1997, 176 (01) :133-143
123