The Newer Fluoroquinolones

被引：43

作者：

Bolon, Maureen K. ^{[1
]}

机构：

[1] Northwestern Univ, Dept Med, Div Infect Dis, Feinberg Sch Med, Chicago, IL 60611 USA

来源：

MEDICAL CLINICS OF NORTH AMERICA | 2011年 / 95卷 / 04期

关键词：

Fluoroquinolones; Antiinfective agents; Pharmacology; Pharmacokinetics; Microbial drug resistance; Therapeutic use; RESISTANT STAPHYLOCOCCUS-AUREUS; DIFFICILE-ASSOCIATED-DIARRHEA; INTENSIVE-CARE UNITS; STREPTOCOCCUS-PNEUMONIAE; CLOSTRIDIUM-DIFFICILE; ESCHERICHIA-COLI; PSEUDOMONAS-AERUGINOSA; QUINOLONE-RESISTANCE; TOPOISOMERASE-IV; HONG-KONG;

D O I：

10.1016/j.mcna.2011.03.006

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Clinicians have enthusiastically used fluoroquinolones owing to their good safety profile and wide range of indications. This article reviews fluoroquinolone pharmacology, pharmacodynamic principles, and fluoroquinolone resistance mechanisms, highlighting recent trends in the epidemiology of fluoroquinolone resistance among gram-negative organisms and Streptococcus pneumonia. Important fluoroquinolone safety concerns are discussed, along with indications for the most commonly used fluoroquinolones-ciprofloxacin, levofloxacin, and moxifloxacin.

引用

页码：793 / +

页数：26

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