Quantitative NMR spectroscopy - Applications in drug analysis

被引：257

作者：

Holzgrabe, U ^{[1
]}

Deubner, R ^{[1
]}

Schollmayer, C ^{[1
]}

Waibel, B ^{[1
]}

机构：

[1] Univ Wurzburg, Inst Pharm & Food Chem, D-97074 Wurzburg, Germany

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2005年 / 38卷 / 05期

关键词：

qNMR; drugs; identification; quantification; impurities;

D O I：

10.1016/j.jpba.2005.01.050

中图分类号：

O65 [分析化学];

学科分类号：

070302 [分析化学]; 081704 [应用化学];

摘要：

NMR spectroscopy being a primary ratio method of measurement is highly suitable to evaluate the quality of drugs. NMR spectroscopy can be used for the identification of a drug substance, the identification and quantification of impurities arising from the synthesis pathway and degradation, or residual solvents as well as the determination of the content in the assay. This review gives an overview of the application of quantitative NMR spectroscopy in International Pharmacopoeias and for licensing purposes. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：806 / 812

页数：7

共 33 条

[1]

ONE-DIMENSIONAL AND 2-DIMENSIONAL H-1-NUCLEAR AND C-13-NUCLEAR MAGNETIC-RESONANCE (NMR) ANALYSIS OF VITAMIN-E RAW-MATERIALS OR ANALYTICAL REFERENCE-STANDARDS [J].

BAKER, JK ;

MYERS, CW .

PHARMACEUTICAL RESEARCH, 1991, 8 (06) :763-770

[2]

BALOGH G, 2000, IDENTIFICATION DETER, P441

[3]

BOSCHETTI C, 1995, ARZNEIMITTEL-FORSCH, V45-2, P1217

[4]

DAWSON BA, 1995, J PHARMACEUT BIOMED, V13, P395, DOI 10.1016/0731-7085(95)01268-P

[5]

Micellar electrokinetic capillary chromatography, high performance liquid chromatography and nuclear magnetic resonance - three orthogonal methods for characterization of critical drugs [J].

Deubner, R ;

Holzgrabe, U .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2004, 35 (03) :459-467

[6]

*EUR PHARM, 2004, EUR DEP QUAL MED

[7]

APPLICATION OF THE WATR TECHNIQUE FOR WATER SUPPRESSION IN H-1-NMR SPECTROSCOPY IN DETERMINATION OF THE KINETICS OF HYDROLYSIS OF NEOSTIGMINE BROMIDE IN AQUEOUS-SOLUTION [J].

FERDOUS, AJ ;

WAIGH, RD .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1993, 45 (06) :559-562

[8]

Stability of commercial solutions of 5-fluorouracil for continuous infusion in an ambulatory pump [J].

Fournet, A ;

Gilard, V ;

Malet-Martino, M ;

Martino, R ;

Canal, P ;

De Forni, M .

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2000, 46 (06) :501-506

[9]

Chemical stability and fate of the cytostatic drug ifosfamide and its N-dechloroethylated metabolites in acidic aqueous solutions [J].

Gilard, V ;

Martino, R ;

Malet-Martino, M ;

Niemeyer, U ;

Pohl, J .

JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (14) :2542-2560

[10]

Hanna GM, 2001, PHARMAZIE, V56, P700

← 1 2 3 4 →