A highly stereoselective hydrogen-bond-mediated Michael-Michael cascade process through dynamic kinetic resolution

被引：168

作者：

Wang, Jian ^{[1
]}

Xie, Hexin ^{[1
]}

Li, Hao ^{[1
]}

Zu, Liansuo ^{[1
]}

Wang, Wei ^{[1
]}

机构：

[1] Univ New Mexico, Dept Chem & Biol Chem, Albuquerque, NM 87131 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 22期

关键词：

cascade reactions; kinetic dynamic resolution; Michael addition; organocatalysis;

D O I：

10.1002/anie.200800381

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Oh Mickey, you're so fine: The title reaction, which is efficiently catalyzed by a cinchona alkaloid thioure affords direct access to thiochromanes in high efficiency. The reaction features a new activation mode of organocatalytic dynamic kinetic resolution involving a Michael-retro-Michael-Michael-Michael cascade. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4177 / 4179

页数：3

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