Solid-phase synthesis of dehydropeptide, AM-toxin II, using a novel selenyl linker by side-chain tethered strategy

被引：16

作者：

Horikawa, E

Kodaka, M

Nakahara, Y

Okuno, H

Nakamura, K

机构：

[1] Natl Inst Adv Ind Sci & Technol AIST, Tsukuba, Ibaraki 3058566, Japan

[2] Sci Univ Tokyo, Fac Ind Sci & Technol, Chiba 2788510, Japan

[3] Tokai Univ, Dept Ind Chem, Kanagawa 2591292, Japan

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 47期

关键词：

AM-toxin; solid-phase synthesis; dehydropeptide; cyclic peptide; selenyl linker;

D O I：

10.1016/S0040-4039(01)01790-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The cyclic dehydrodepsipeptide, AM-toxin II, was efficiently synthesized by a solid-phase method using a novel selenyl linker. The cleavage from the resin with formation of a double bond is successfully achieved under mild oxidative conditions with TBHP. (C) 2001 Elsevier Science Ltd. All rights reserved.

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收藏

页码：8337 / 8339

页数：3

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