Sequential Signaling Crosstalk Regulates Endomesoderm Segregation in Sea Urchin Embryos

被引：50

作者：

Sethi, Aditya J. ^{[1
]}

Wikramanayake, Radhika M. ^{[2
]}

Angerer, Robert C. ^{[1
]}

Range, Ryan C. ^{[1
]}

Angerer, Lynne M. ^{[1
]}

机构：

[1] NIDCR, NIH, Bethesda, MD 20892 USA

[2] Univ Oxford, Dept Publ Hlth, Oxford, England

来源：

SCIENCE | 2012年 / 335卷 / 6068期

关键词：

NUCLEAR BETA-CATENIN; GENE NETWORK; VEGETAL PLATE; SPECIFICATION; ENDODERM; NOTCH; INDUCTION; CELLS; MESENDODERM; ACTIVATION;

D O I：

10.1126/science.1212867

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The segregation of embryonic endomesoderm into separate endoderm and mesoderm fates is not well understood in deuterostomes. Using sea urchin embryos, we showed that Notch signaling initiates segregation of the endomesoderm precursor field by inhibiting expression of a key endoderm transcription factor in presumptive mesoderm. The regulatory circuit activated by this transcription factor subsequently maintains transcription of a canonical Wnt (cWnt) ligand only in endoderm precursors. This cWnt ligand reinforces the endoderm state, amplifying the distinction between emerging endoderm and mesoderm. Before gastrulation, Notch-dependent nuclear export of an essential beta-catenin transcriptional coactivator from mesoderm renders it refractory to cWnt signals, insulating it against an endoderm fate. Thus, we report that endomesoderm segregation is a progressive process, requiring a succession of regulatory interactions between cWnt and Notch signaling.

引用

收藏

页码：590 / 593

页数：4

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