Breast cancer stem cells

被引：198

作者：

Velasco-Velazquez, Marco A. ^{[1
,2
]}

Homsi, Nora ^{[1
]}

De La Fuente, Marisol ^{[3
]}

Pestell, Richard G. ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Dept Canc Biol, Kimmel Canc Ctr, Philadelphia, PA 19107 USA

[2] Univ Nacl Autonoma Mexico, Fac Med, Dept Farmacol, Mexico City 04510, DF, Mexico

[3] Temple Univ, Sch Med, Shriners Hosp Pediat Res Ctr, Philadelphia, PA 19122 USA

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2012年 / 44卷 / 04期

关键词：

Breast cancer; Cancer stem cell; Metastasis; Resistance; Breast cancer therapy; EPITHELIAL-MESENCHYMAL TRANSITION; CYCLIN D1; SELF-RENEWAL; MAMMARY STEM; IN-VITRO; METASTASIS; EXPANSION; TUMORIGENESIS; EXPRESSION; CULTURE;

D O I：

10.1016/j.biocel.2011.12.020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Breast cancer stem cells (BCSCs) constitute a subpopulation of tumor cells that express stem cell-associated markers and have a high capacity for tumor generation in vivo. Identification of BCSCs from tumor samples or breast cancer cell lines has been based mainly on CD44(+)/CD24(-/low) or ALDH(+) phenotypes. BCSCs isolation has allowed the analysis of the molecular mechanisms involved in their origin. self-renewal, differentiation into tumor cells, resistance to radiation therapy and chemotherapy, and invasiveness and metastatic ability. Molecular genetic analysis using knockout animals and inducible transgenics has identified NF-kappa B, c-Jun, p21(C1P1), and Forkhead-like-protein Dach1 involvement in BCSC expansion and fate. Clinical analyses of BCSCs in breast tumors, have found a correlation between the proportion of BCSCs and poor prognosis. Therefore, new therapies that specifically target BCSCs are an urgent need. We summarize recent evidence that partially explain the biological characteristics of BCSCs. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：573 / 577

页数：5

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