Rate of cognitive decline in AD is accelerated by the interleukin-1α-889*1 allele

被引：49

作者：

Murphy, GM ^{[1
]}

Claassen, JD

DeVoss, JJ

Pascoe, N

Taylor, J

Tinklenberg, JR

Yesavage, JA

机构：

[1] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Neurosci Res Labs, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Grad Program Immunol, Stanford, CA 94305 USA

[3] Dept Vet Affairs Sierra Pacific Mental Illness Re, Educ & Clin Ctr, Palo Alto, CA USA

来源：

NEUROLOGY | 2001年 / 56卷 / 11期

关键词：

D O I：

10.1212/WNL.56.11.1595

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The reason for differences in rate of cognitive decline in AD is unknown. The interleukin-1 alpha (IL-1 alpha) -889 *2 allele is associated with increased risk for AD. Surprisingly, in a sample of 114 patients followed for an average of 3.8 years, individuals homozygous for the IL-1 alpha -889 *1 allele declined significantly more rapidly on the Mini-Mental State Examination than did others. There was no difference in rate of decline between patients with and without the APOE is an element of4 allele. These results support the hypothesis that inflammation is important in the clinical course of AD.

引用

页码：1595 / 1597

页数：3

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