Treating the Host Response to Ebola Virus Disease with Generic Statins and Angiotensin Receptor Blockers

被引：49

作者：

Fedson, David S.

Jacobson, Jeffrey R. ^{[1
]}

Rordam, Ole Martin

Opal, Steven M. ^{[2
]}

机构：

[1] Univ Illinois, Coll Med, Chicago, IL USA

[2] Brown Univ, Alpert Med Sch, Providence, RI 02912 USA

来源：

MBIO | 2015年 / 6卷 / 03期

关键词：

DYSFUNCTION; ATORVASTATIN; INFLAMMATION; COMBINATION; SEPSIS;

D O I：

10.1128/mBio.00716-15

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

Treatments targeting the Ebola virus may eventually be shown to work, but they will not have an impact on overall Ebola mortality in West Africa. Endothelial dysfunction is responsible for the fluid and electrolyte imbalances seen in Ebola patients. Because inexpensive generic statins and angiotensin receptor blockers restore endothelial barrier integrity, they can be used to treat the host response in these patients. In Sierra Leone, approximately 100 Ebola patients were treated with this combination, and reports indicate that survival was greatly improved.

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页码：1 / 4

页数：4

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